At present, there are NMN, valerian root extract and other products on the market for improving sleep, all of which have a certain audience, and everyone has some certainty about the curative effect, but there are some limitations.
Sleep disorder is a common disease. This disease has two manifestations, one is too much sleep (drowsiness), and the other is too little sleep (insomnia). Each has its own etiology. In this article, we mainly discuss Issues related to insomnia.
Factors that affect insomnia include mental problems, behavioral stress problems, drug abuse or adverse side effects, stomach pain, abnormal heart function and other diseases that lead to secondary sleep disorders, abnormal biological clocks such as working day and night upside down, bad schedules, and no specific obvious reasons.
When sleep disorders occur, our body temperature regulation will be impaired, the immune system will change, and our health will be endangered, resulting in poor energy, poor immunity, increased blood pressure, heart attack, anxiety and depression, etc. For people with insomnia, we are generally required to change our daily living habits and environment first. If it still cannot be improved, we need to give appropriate treatment for the cause, such as drug therapy, behavioral psychotherapy, etc. However, drugs often have relatively large side effects. Then some people will choose to use some health products to help improve sleep. These products are melatonin, valerian root powder bulk, NMN.
1. Mechanism of action of valerian root on sleep
Valerian root, a traditional Chinese medicinal material, mainly treats restlessness, lumbago, spasm, weak stomach, dryness of viscera, rheumatic arthralgia, irregular menstruation, and traumatic injuries. The medicinal properties are pungent and warm, slightly toxic, rhizome type, with a special odor, the taste is sweet at first and then slightly bitter.
It has the effects of calming the nerves, relieving spasm and relieving pain. Its medicinal active ingredients: alkaloids (actinine, valerianine), flavonoids, γ-aminobutyric acid, isovaleramide, essential oils.
Valerian relieves insomnia, sleep disturbances, anxiety, and other disorders, while also relaxing muscles and restoring homeostasis. Valerian has traditionally been used to treat gastrointestinal pain and irritable bowel syndrome. It has antibacterial effect and is effective against Gram-positive bacteria. It also has the effect of lowering blood pressure.
At present, Europe and the United States and other countries are mainly used as sedative and hypnotic drugs. The drug has no hangover effect and has been included in the American and European pharmacopoeias. Europe and the United States and other countries use valerenic acid as the quality control index, while in my country, valerian is mainly used for sedative and hypnotic sleep.
It has a relatively clear sedative effect on the nervous system, can strengthen the inhibition process of the cerebral cortex, reduce reflex excitability, and relieve smooth muscle spasm. Valerian itself does not induce sleep in animals, but it can enhance the sleep time of barbiturates and inhibit the general activities of animals. So far, there is no clear mechanism for sedation and improvement of insomnia. It is speculated that some components of valerian extract seem to have affinity for GABA receptor complexes (including benzodiazepine receptors), and the relatively high content of γ-aminobutyrate Acid (GABA) itself is mediated.
May cause allergies such as skin rashes, hives and even difficulty breathing in some people. Long-term can cause stomach pain, slow response or mild depression, occasionally headache, drowsiness, hypothermia, walking disorder, palpitations, fatigue, liver dysfunction, addiction, etc. Contraindicated in patients with liver dysfunction. It should not be used simultaneously with alcohol, benzodiazepines, barbiturates and other inhibitors. People with constitutional yin deficiency should use it with caution.
2. The mechanism of NMN on sleep
NMN nicotinamide mononucleotide is a kind of or naturally occurring biologically active nucleotide, which has two irregular forms, α and β, which belong to the category of vitamin B derivatives. It is widely distributed in daily food, and is rich in cauliflower, Chinese cabbage, avocado and tomato. It is widely involved in many biochemical reactions in the human body in daily food, and is closely related to immunity and metabolism. It is the precursor substance of NAD+.
NMN can improve sleep disorders caused by circadian rhythm reversal or age growth, activate DNA repair pathway PARPS, synthesize NADP+ to resist oxidative damage, activate histone deacetylase SIRTUINS, reverse vascular aging, protect liver and kidney, and skeletal muscle anti-aging , Protect the damaged heart, etc.
Applicable people for sleep disorders are relatively suitable for the elderly or jet lagged, and a small number of people who improve their sleep will experience recurrence.
To sum up, for products that improve insomnia, valerian root extract can buy.
