Many hepatitis patients in modern society, such as hepatitis C patients and hepatitis B patients, are accompanied by liver fibrosis and cirrhosis; some people drink alcohol for a long time, the liver is damaged, and they suffer from alcoholic liver; fatty liver is even more common. There are many patients like this who come to consult me, for such patients, what can protect the liver for a long time. To this end, I searched a large number of literature, and finally selected best milk thistle powder as the best choice for long-term liver protection.
1. Protect liver cell membrane
The liver is the organ responsible for metabolism and detoxification in the body. All substances that enter the body need to be metabolized and detoxified by the liver, which also means that the liver will face more toxic substances. These toxic substances will most likely start from the liver cell membrane. It affects the normal functioning of the liver by blocking the liver's transport function and fluidity and enterohepatic circulation. The substances in milk thistle can help the liver maintain the fluidity of the cell membrane by anti-lipid peroxidation, which is conducive to stabilizing and protecting the liver cell membrane.
2. Prevent Liver Damage
Even if the food eaten is free of toxins, what people eat can place a considerable burden on the liver. For example, some high-calorie and high-fat foods are more difficult to metabolize and digest, and will bring excess calories to the body. If they are not fully consumed, a large amount of fat will be accumulated in the body, which will also bring a burden to the liver. Over time, it will cause a lot of damage. The substances in milk thistle can help the liver prevent these damages and have a protective effect on the liver.
3. Promote liver cell regeneration and repair
When the liver is damaged and requires self-regulation and regeneration repair, silymarin can bind to the receptor of estradiol in liver cells, promote the synthesis of structural proteins and enzymes, and indirectly promote the synthesis of cell DNA. In this way, it is very helpful for the self-repair and regeneration of the liver.
4. Immunomodulatory effect
Studies have shown that ethanol adducts produced during ethanol metabolism can be used as foreign antigens to stimulate the body's immune system, increasing the number and activity of cytotoxic T lymphocytes (CTL) and natural killer cells in the body, and enhancing the immune system of liver cells. Increased sexual damage. After treatment with silymarin, the number and activity of CTL and NK cells in the blood are weakened, so it is speculated that the drug also has a corresponding immune regulation function.
Hepatoprotective Action Mechanism of bulk milk thistle powder
The most important ingredient in milk thistle is silibinin. So how does it protect the liver? Silibinin induces the SIRT1/AMPK pathway in high-fat diet-fed mice and palmitate-treated HepG2 cells. Silibinin, which activates FXR signaling or AMPK phosphorylation, regulates lipid metabolism in rodents fed a high-fat diet. Silibinin can inhibit NLRP3 signaling and reduce inflammation. Silibinin, an antioxidant, increases NRF2 translocation in the liver of methionine- and choline-deficient diet-fed mice. Here again, it is easy to understand, that is, it can regulate liver cell death, regulate lipid cell metabolism, resist liver inflammation, resist oxidative stress in the liver, and regulate the microecology of the entire liver. So silybin is a very comprehensive liver protection ingredient.
Based on the above, in the following scenarios, milk thistle can generally be used to maintain the liver:
People who drink frequently, the liver of people who drink alcohol is more prone to alcohol poisoning, and long-term drinking will lead to fatty liver.
Those who work in some chemical factories are often exposed to some organic toxic substances, but in fact they are finally metabolized in the liver.
People who work overtime and stay up late mainly fight against the oxidative stress response in the liver, and can also regulate the microecology of the liver and the microecology of the intestinal tract. People who stay up late are prone to digestive disorders.
People who take medicine frequently, because the metabolizing organ of medicine is generally the liver. People with fatty liver, liver cirrhosis, and hepatitis can also use it for maintenance.
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